Drug Delivery Systems: The Accelerator for Drug Development and Innovative Applications
Drug Delivery System, the Rookie with the Greatest Commercial Potential among Pharmaceutical Technologies
In drug development, besides the super star: drug discovery, there are other crucial items which have been attracting researchers to conduct studies focusing on several topics such as derivative discovery, drug repositioning, and formulation development. In recent years, drug delivery systems (DDS) are one of the most influential items with great commercial potential. Drug development is heading toward to the more precise performance, better efficacy, fewer side effects, and longer duration of efficacy through the development of new dosage forms, new drug carriers, and new drug delivery systems. The meteoric growth of material development and system development makes drug delivery system become more diversified than before. The well- developed DDSs make medicine be released with right quantity at right time and right sites. New DDSs can be applied to a variety of dosage forms like oral forms, topical forms, and injections and remarkably increase the therapeutic effect. According to the report from GBI Research, the drug delivery system market had been increased from US$ 101 billion in 2009 to US$ 199 billion in 2016. The average compound annual growth rate was 10.2%.
Liposomes, the Rising Star in Drug Delivery Systems
Liposomes are the something you should know when it comes to the development of modern drug delivery systems. A liposome is a spherical vesicle having at least one lipid bilayer which diameter ranges from 0.025 to 3.5μm. The liposome can be used as a vehicle for administration of pharmaceutical drugs. The drugs will be released to treat the illness after the liposome – the vesicle have passed through the cell membrane or engulfed by a macrophage. Liposomes are mainly composed of phospholipids. The phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. These features enable liposomes to be the carriers of hydrophobic and hydrophilic drugs. With the benefits brought by liposomes and better technologies, technological innovations have been developed for delivering cytotoxic drugs.
Some pharmaceutical manufacturers have combined liposomes with tumor-targeted antibodies to treat tumors. Targeted liposomes can carry drugs into tumors precisely to avoid side-effects. In addition, targeted liposomes can remarkably improve the therapeutic effect by its higher drug carrying capacity. The liposome technology is also applied to the development of new vaccines, genetic therapy, and immunoregulatory drugs etc.
Targeted Liposomes Avoid Side-effects of Cancer Drugs
The Classic Case: Liposomal Doxorubicin
Doxorubicin is a traditional chemotherapy medication used to treat a range of cancers. However its cytotoxicity is too strong to avoid harms to normal tissues and organs. In addition to killing cancer cells, it also causes serious side effects which are commonly identified in patients during chemotherapy. The side effects include hair loss, vomiting, and mucosal inflammation. Furthermore, it also has cardiotoxicity and the severity of cardiotoxicity depends on its cumulative dose. The risk can be lethal if the cumulative dose is high enough. Nowadays, liposomal doxorubicin has been developed to carry doxorubicin with liposomes which average diameter is around 100μm. The moderate size of liposomes makes it like a guided missile which directly carries cancer drugs into tumors with larger gaps in vascular walls to target and kill cancer cells. Liposomal doxorubicin also prevents normal cells from the damages caused by the penetration of drugs during transportation. It not only provides a long-term therapeutic effect and better performance in killing tumors, but also avoids most side effects brought by a chemotherapy medication. These benefits include reduced percentage of having hair loss by 90% and reduced heart damages by 1 to 10. Owing to these great benefits, the demands for liposomal doxorubicin are steadily growing year by year. According to the research report from Grand View Research, the compound annual growth rate of liposomal doxorubicin is 6.2% in the US. The market size is gradually increasing.
The Latest Study: Liposomal Paclitaxel
Paclitaxel is another crucial chemotherapy medication used to treat a range of cancers. To tackle with its hydrophobic feature, an ingredient which has been recognized as being responsible for the allergic reactions was added into its initial drug formulation. Based on the latest studies, some researchers used liposomes to carry paclitaxel and discarded the ingredient which causes allergic reactions. The liposomal paclitaxel not only has same therapeutic effect, but also reduce the occurrence of side effects. This major breakthrough had been published in one of the top scholarly journals, Science Translational Medicine. We have a great chance to develop a more effective cancer drug with fewer side effects!
Liposomes: The New Era of Cosmetic Industry
The Compound Dosage Form Carries both Hydrophobic and Hydrophilic Solutes, Successfully Solves the Bad Absorption of Topical Skin Care Products
Liposomes are not only used to drug development, the competitive characteristic also grabs people's attention in cosmetic industry. Liposomes create a bandwagon for skin care products. Some nutrients used in topical skin care products are incapable to be absorbed by skin such as hyaluronan (a macromolecule) and vitamin C (a hydrophilic molecule). But now these nutrients can pass the sebum on the surface of the skin to the hypodermis through liposomes, the drug delivery technology, and be absorbed completely to keep moisture and fight against aging. Decorte launched the moisturizing essence with liposomes. It gradually releases moisturizing ingredients and keeps your skin dewy through the 0.1 μm liposomes which carry ingredients to pass the horny layer. Sesderma launched C-VIT Liposomal Serum with liposomes carrying vitamin C and several anti-aging ingredients. The liposomes help these ingredients penetrate into the skin effectively and be absorbed completely. The Japanese manufacturer, Blanche Blanche, has developed the dense essence with additional 5 peptides and liposomes carrying ceramide. It successfully captures consumers' attention.
The Application Case: 5 Minute Facial Mask with Instant Efficacy
Besides essences, liposomes are also applied to the development of facial masks. TCI uses our cutting- edge manufacturing process to increase the production capacity and makes the price become affordable for people. We are the pioneer who firstly uses liposomes carrying all ingredients in our essences. The features such as the small diameter and the good permeability make the essence can be penetrated into skin cells quickly. With LipoMaskTM technology, the time of applying a sheet mask is reduced from 15 minutes to 5 minutes. The LipoMaskTM of TCI, the exclusive facial mask product with instant efficacy, obtained the Gold Medal and the Special Prize of the 32th World Genius Convention and Education Expo. Our technology gains high reputation across the globe.