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Custom Probiotics: to Maintain the Health of our Second Brain, the "Digestive System"

Probiotics, any active micro organism that promotes the balance of intestinal flora and increases the health benefits of the host, can also be said to be one of the most important "organs" in the human body. Not only found in the intestines, probiotics also in the reproductive organs, respiratory tract, and skin.

probiotics vs. weight of major human organs

Data Source: Practical Anti-infective Therapy

Distribution of Probiotics

Data Source: Practical Anti-infective Therapy

Human Intestinal Flora is Closely Related to the Vital Functions of the Body

In recent years, research related to probiotics and diseases on other body parts has also been continuously discovered. In view of the wide-ranging impact of probiotics on human health, the health and nutrition industry is able to develop a wide range of probiotic products.

Data Source: Nature Science, Sorted by TCI

Probiotics and Disease Research Papers Published in the Past 5 Years

Data Source: Pubmed

Out side the digestive care is still a blue ocean

According to the survey, most consumers know probiotics, but most only recognize them for gastrointestinal health care. Currently, custom probiotic-related products on the market are also mainly for gastrointestinal health care. For example, in 2015, from global probiotic health related products more than 78% were new products for digestive care.

2015 probiotics health food appeal

source:innova marketing insight, 2016

H&M LAB

Human & Microbiome Laboratory

A new concept of gastrointestinal health: Probiogenics = Probiotics + Prebiotics + Biogenics.

The Human Microbiome Laboratory primarily focuses on the establishment of a versatile bank of multifunctional microbial strains.Through active screening of probiotics and the natural flora function feedback loop,our development of target-specific microfloral adjustment and modification from selective bacterial manipulation truly benefit each individual from a personal scope.

TCI's Exclusive Special Probiotic Bacterial Strains Offer Powerful Physiological Benefits

TCI-633
TCI-507
TCI-357
TCI-378

Streptococcus thermophilus, which is acid-, heat-resistant and not pathogenic, is widely used in dairy industry without safety concern.TCI Co., Ltd isolated Streptococcus thermophilus TCI-633 from human breast milk and is named HA Pro-Genesis™. The efficacy of Streptococcus thermophilus TCI-633 was evaluated by in vitro and clinical studies.

We examined the difference in Hyaluronic acid (HA) producing ability between HA Pro-Genesis and S. thermophilus YIT2084. The results showed that HA Pro-Genesis could produce 270 times HA quantity than the other strain in reference.

Comparison of the HA-producing ability by S. thermophilu.
Time courses of cell concentration and produced hyaluronic acid (HA) concentration by HA Pro-Genesis™.

TCI-507 are probiotics found on orange peel that can survive in stomach and modulate immune responses suppressing inflammatory bowel diseases. e growth of L. plantarum in gastrointestinal tract modulates the composition of gut microbiota by inhibiting the growth of harmful bacteria. An additional benefit of L. plantarum has been reported by studies showing their capacity to lower blood cholesterol and LDL-C levels.

Six subjects whose total cholesterol level above 190 mg/dL were involved in this study. they were instructed to take a capsule of TCI-507 after meal every day for 4 weeks. The results showed that their total cholesterol levels were decreased by 7.1% and 7.2% after taking the capsules for 2 and 4 weeks. As for LDL-C levels, reduction of 7.2% and 11% were observed on the subjects on week 2 and 4, respectively.

The effects of TCI507 on total cholesterol levels on the subjects.
The effects of TCI507 on LDL-C levels on the subjects.

TCI-357 (Lactobacillus helveticus) are probiotics from pear and usually applied in the production of Swiss cheese as seasoning. Several studies have shown that L. helveticus possess various benefits to human health and can alleviate the symptoms of upper respiratory tract infection in winter. Accordingly, TCI-357 have the potential to be developed as lung-protection-relevant unctional ingredients in nutraceuticals.

We co-cultured TCI-357 with THP-1 macrophage cells and fluorescent-labeled microparticles in a certain incubation period in an effort to observe the phagocytic activity of macrophages through fluorescent signals. Based on the experimental result, TCI-357 could facilitate the phagocytic activity of macrophages, which means that TCI357 can be used for disposing of microparticles in lungs and preventing lung damage from PM2.5.

Improvement in phagocytic activity of macro- phages by TCI357 (PM 2.5).

TCI-378 (Lactobacillus plantarum) is a probiotics, isolated from kimchi. L. plantarum. TCI-378 has ability to inhibit pathogenic microorganisms, it helps prevent disease. Additionally, L. plantarum maintains the balance of bacteria in intestinal, which promote the intestinal tract health. In the other hands, TCI-378 was able to reduce fat absorption and body fat storage.

Inhibitory activity of lipid synthesis in adipocytes, 3T3-L1, was increased when grew the cells with TCI-378. TCI-378 inhibited 15% of lipid synthesis compared to the control. Furthermore, TCI-378 reduced 47.6% cholesterol level in medium containing cholesterol (MRSC), indicating TCI-378 increased fat metabolism, and reduced lipid absorption.

TCI378 was able to hydrolyzed bile salts and reduce emulsification.
Inhibitory effect of TCI378 on lipid synthesis.

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What Can TCI Do for You?

Developing Differentiated Organic Probiotic Supplement Products

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